- A swab is used to take a sample from the patient (typically nasopharyngeal)<\/li>
- Swab is inserted into a saline solution to remove collected sample<\/li>
- Reagents for the amplification process are added<\/li>
- Device heats reaction chamber and a colorimetric detector determines color change over a specific run time<\/li>
- Device outputs positive or negative result depending on color change<\/li><\/ol>\n<\/div>\n<\/div>\n\n\n\n
The following are sketches of possible design solutions:<\/p>\n\n\n\n
Handheld with Test Tube Reaction Chamber<\/h2>\n\n\n\n
\n\n![\"First](\"http:\/\/engprojects.tcnj.edu\/poc-dectection-device-2023\/wp-content\/uploads\/sites\/219\/2022\/11\/Handheld-with-Test-Tube-Design-Solution-1024x546.png\")
<\/figure>\n<\/div>\n\n\n\n\nKey Features:<\/p>\n\n\n\n
- Patient sample is added with reagents to a optically clear PCR tube<\/li>
- User manually mixes reagents before inserting tube into device<\/li>
- Ergonomic handheld design<\/li><\/ul>\n<\/div>\n<\/div>\n\n\n\n
After discussing all design solutions, this option scored the highest on a decision matrix and had the most favorable customer input.<\/strong> The finalized schematic of the device using this design is in progress.<\/strong><\/p>\n\n\n\n
Handheld with Custom Cartridge Reaction Chamber<\/h2>\n\n\n\n
\n\n![\"Second](\"http:\/\/engprojects.tcnj.edu\/poc-dectection-device-2023\/wp-content\/uploads\/sites\/219\/2022\/11\/Handheld-with-Cartridge-Design-Solution-1024x658.png\")
<\/figure>\n<\/div>\n\n\n\n\nKey Features:<\/p>\n\n\n\n
- Patient sample is added to a cartridge preloaded with reagents<\/li>
- Reagents are released into patient sample during heating process<\/li>
- Ergonomic handheld design<\/li><\/ul>\n<\/div>\n<\/div>\n\n\n\n
Portable Compact Briefcase Design<\/h2>\n\n\n\n
\n\n![\"Third](\"http:\/\/engprojects.tcnj.edu\/poc-dectection-device-2023\/wp-content\/uploads\/sites\/219\/2022\/11\/Portable-Briefcase-Design-Solution-1024x676.png\")
<\/figure>\n<\/div>\n\n\n\n\nKey Features:<\/p>\n\n\n\n
- A durable polycarbonate case would contain all components needed for testing<\/li>
- Utilizes a test tube reaction chamber where the user would manually setup the test outside of the device<\/li>
- Analyzer is not handheld<\/li><\/ul>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"
Several alternative design solutions were devised that could meet the design requirements of the PG-Detect device. All of the designs have the same overall functionality outlined below: A swab is used to take a sample from the patient (typically nasopharyngeal) Swab is inserted into a saline solution to remove collected sample Reagents for the amplification … <\/p>\n